Publications / Presentations

Selected Peer-reviewed Publications

Ben G.Small, Barry W.McColl, Richard Allmendinger, Juergen Pahle, Gloria Lopez-Castejon, Nancy J Rothwell, Joshua Knowles, Pedro Mendes, David Brough, Douglas B Kell.  (2011).  Efficient discovery of anti-inflammatory small molecule combinations using evolutionary computing.  Nat.Chem Biol.  (Accepted).

Hardy ME, Small BG, Valentin JP, Pollard CE, Abi-Gerges N. (2009). Validation of a voltage-sensitive dye-based method for assessing dog myocyte action potential duration.  J. Pharmacol & Toxicol Methods. 58(2), 156.

Small, B.G., Barone, L., Pollard, C.E., Valentin, J.P. and Ciaccio, P. (2007). A comparison
in compound potency between the hERG encoded K+ channel and an in vitro phospholipidosis assay. Brit. J. Pharmacol. 073P.

Abi-Gerges, N., Small, B.G., Lawrence, C.L., Hammond T.G., Valentin J.P. and Pollard C.E.  (2006). Gender dierences in the slow delayed (I(Ks)) but not in inward (I(K1)) rectier K+ currents of canine Purkinje bre cardiac action potential: key roles for I(Ks), beta-adrenoceptor stimulation, pacing rate and gender. Brit. J. Pharmacol. 147(6), 653-660.

Abi-Gerges, N., Small, B.G., Lawrence, C.L., Hammond, T., Valentin, J.P. and Pollard, C.E.  (2003). Evidence for gender differences in the electrophysiological properties of canine Purkinje fibres. Brit. J. Pharmacol. 142(8),1255-64.

Small, B.G., Thomas, J., Kemp, M., Hoo, K., Ballyk, B., Deverill, K., Ogden, D., Rubio, P.,
Pedregal, C. and Bleakman, D. (1998). LY339434, a GluR5 kainate receptor agonist. Neuropharmacology. 37, 1261-7.

Small, B.G. et al. (1997). LY339434, a GluR5-selective kainate receptor agonist. Brit.J.Pharmacol. 122, 59P.

Small, B.G., Fillipov, A.K., Lodge, D and Bleakman, D. (1996). ATP-dependent increases in intracellular calcium concentration [Ca2+]i in HEK293 cells. Brit. J. Pharmacol. 120, 162P.

Proceedings, Commentaries and Oral Presentations

Bryn Nelson. Interdisciplinary studies: Seeking the right toolkit. (2011). Nature. 476. 115 -117. Interviewed by a Nature journalist concerning the risks and rewards of pursuing interdisciplinary studies.

B.G.Small, J.Pahle, G.Lopez-Castejon, D.Brough, D.B.Kell, N.J.Rothwell, J.Knowles, R.Allmendinger, P.Mendes and B.W.McColl. (2010). Evolution directed inhibition of IL-1 expression. Chemical Biology 2010, Heidelberg, Germany, 22nd – 25th September 2010. EBML-ATC, Heidelberg, Germany.

B.G.Small. New molecules in the Neckar. A review of the EMBO Chemical Biology 2010 Conference held at EMBL Heidelberg 22nd – 25th September 2010.

Small, B.G. (2010). Chemical Biology of IL-1 expression. MIB Internal Seminar Series. Sponsored by Sera Labs.